Overview
Diindolylmethane is made in the body from a chemical called indole-3-carbinol, which is found in cruciferous vegetables such as cauliflower and broccoli.
Diindolylmethane might act like estrogen in the body, but might also block estrogen effects. It appears to help destroy cancer cells and reduce swelling.
People commonly use diindolylmethane for breast cancer, prostate cancer, and many other conditions, but there is no good scientific evidence to support these uses.
Uses & Effectiveness ?
We currently have no information for DIINDOLYLMETHANE overview.
Side Effects
When taken by mouth: Diindolylmethane is commonly consumed in foods. A typical diet supplies 2-24 mg of diindolylmethane daily. It is possibly safe for most people when taken in doses up to 150 mg daily for up to 1 year. The most common side effects include headache, nausea, vomiting, gas, and diarrhea.
Taking larger doses of diindolylmethane is possibly unsafe. Taking 600 mg of diindolylmethane daily might lower sodium levels in some people.
Special Precautions and Warnings
When taken by mouth: Diindolylmethane is commonly consumed in foods. A typical diet supplies 2-24 mg of diindolylmethane daily. It is possibly safe for most people when taken in doses up to 150 mg daily for up to 1 year. The most common side effects include headache, nausea, vomiting, gas, and diarrhea.
Taking larger doses of diindolylmethane is possibly unsafe. Taking 600 mg of diindolylmethane daily might lower sodium levels in some people. Pregnancy and breast-feeding: Diindolylmethane is commonly consumed in foods. There isn't enough reliable information to know if larger amounts are safe to use when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.
Children: Diindolylmethane is commonly consumed in foods. There isn't enough reliable information to know if larger amounts are safe.
Hormone-sensitive conditions: Diindolylmethane might act like estrogen, so it might make hormone-sensitive conditions worse. These conditions include breast cancer, cancer of the uterus, ovarian cancer, a painful uterine disorder (endometriosis), or non-cancerous growths of the uterus (uterine fibroids). Until more is known, don't use diindolylmethane if you have a hormone-sensitive condition.
Interactions ?
Water pills (Diuretic drugs) interacts with DIINDOLYLMETHANE
Diindolylmethane can decrease sodium levels. "Water pills" can also decrease sodium levels. Taking "water pills" along with diindolylmethane might make sodium levels drop too low.
Estrogens interacts with DIINDOLYLMETHANE
Diindolylmethane might have effects similar to estrogen. But in some cases, diindolylmethane might oppose the effects of estrogen. Taking large amounts of diindolylmethane might interfere with hormone replacement therapy.
Moderate Interaction
Be cautious with this combination
Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with DIINDOLYLMETHANE
Some medications are changed and broken down by the liver. Diindolylmethane might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Minor Interaction
Be watchful with this combination
Dosing
Diindolylmethane is naturally made in the stomach after eating vegetables that contain the chemical called indole-3-carbinol. Vegetables that contain this chemical include broccoli, cabbage, cauliflower, kale, and Brussels sprouts. A typical diet supplies 2-24 mg of diindolylmethane daily.
In supplements, diindolylmethane has most often been used by adults in doses of 100-150 mg by mouth daily for 1-12 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.
Next
- Common Searches:
- Alpha Lipoic Acid
- Apple Cider Vinegar
- Black Cohosh
- Calcium
- Chromium
- Coenzyme Q - 10
- DHEA
- Flaxseed
- Folic Acid
- Ginko
- Glucosamine
- Melatonin
- Niacin
- Magnesium
- Probiotics
- Red Yeast Rice
- St. John's Wort
- Vitamin C
- Vitamin D
- Vitamin E
Show More Show Less
You Might Also Like
Preventing HIV: How PrEP Works
Navigating Life With Migraine
Alternative Treatments for Migraines
View More
CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circ*mstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.
This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.
